<![CDATA[1313 GEROPROTECT - What are senolytics]]>Tue, 21 May 2024 11:46:31 -0700Weebly<![CDATA[What are senolytics?]]>Fri, 13 Jan 2023 08:00:00 GMThttp://13-13.org/what-are-senolytics/what-are-senolyticsWhat are senolytics?

Senolytics are a class of drugs or compounds that target and selectively eliminate senescent cells in the body. Senescent cells are cells that have entered a state of irreversible growth arrest and are no longer able to divide or carry out their normal functions. While senescent cells are beneficial in some cases, such as in wound healing and embryonic development, they can also contribute to age-related diseases and tissue dysfunction.

As we age, senescent cells accumulate in various tissues and organs, where they secrete a variety of pro-inflammatory factors and other molecules that can damage nearby cells and tissues. This contributes to the development of many age-related diseases, such as osteoarthritis, Alzheimer's disease, and cardiovascular disease.

Senolytics work by selectively targeting and killing senescent cells, which can help to alleviate inflammation and improve tissue function. Some senolytics have been shown to improve lifespan and healthspan in animal studies, and there is growing interest in their potential as a therapy for age-related diseases.

Examples of senolytic drugs and compounds include dasatinib, quercetin, fisetin, and navitoclax. However, more research is needed to determine their safety and effectiveness in humans, and to develop more potent and specific senolytic therapies.]]>